期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 136, 期 3, 页码 874-877出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja411547j
关键词
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资金
- Howard Hughes Medical Institute
- National Institute of Health (NIH) [5R01CA158448-02]
- Department of Defense (DoD) [W81XWH-09-1-0699]
- NIH [5R25CA153915-03, 1F30HL118998-01]
- American Asthma Foundation [11-0321]
A hydrogen peroxide (H2O2)-activated cell-penetrating peptide was developed through incorporation of a boronic acid-containing cleavable linker between polycationic cell-penetrating peptide and polyanionic fragments. Fluorescence labeling of the two ends of the molecule enabled monitoring its reaction with H2O2 through release of the highly adhesive cell-penetrating peptide and disruption of fluorescence resonance energy transfer. The H2O2 sensor selectively reacts with endogenous H2O2 in cell culture to monitor the oxidative burst of promyelocytes and in vivo to image lung inflammation. Targeting H2O2 has potential applications in imaging and therapy of diseases related to oxidative stress.
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