期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 136, 期 31, 页码 10823-10825出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja412314j
关键词
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资金
- NSF [DGE-0808392]
- UC-Irvine
- Hellman Faculty Fellowship
- NIH New Innovator Award [DP2-AI112194]
The innate immune response is controlled, in part, by the synergistic interaction of multiple Toll-like receptors (TLRs). This multi-receptor cooperation is responsible for the potent activity of many vaccines, but few tools have been developed to understand the spatio-temporal elements of TLR synergies. In this Communication, we present photo-controlled agonists of TLR7/8. By strategically protecting the active agonist moiety based on an agonist-bound crystal structure, TLR activity is suppressed and then regained upon exposure to light. We confirmed NF-kappa B production upon light exposure in a model macrophage cell line. Primary cell activity was confirmed by examining cytokine and cell surface marker production in bone-marrow-derived dendritic cells. Finally, we used light to activate dendritic cell sub-populations within a larger population.
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