期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 135, 期 14, 页码 5364-5367出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja402274g
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资金
- NIGMS NIH HHS [R01 GM080442, GM80442] Funding Source: Medline
The coupling of O-pivaloyl benzhydroxamic acids with donor/acceptor diazo compounds provides isoindolones in high yield. The reaction tolerates a broad range of benzhydroxamic acids and diazo compounds, including substituted 2,2,2-trifluorodiazoethanes. Mechanistic experiments suggested that C-H activation is turnover-limiting and irreversible and that insertion of the diazo compound favors electron-deficient substrates.
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