期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 135, 期 30, 页码 11232-11238出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja404134f
关键词
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资金
- Rackham Merit and American Foundation
- Life Sciences Research Foundation
- Intelligent Synthetic Biology Center of Global Frontier Project
- Ministry of Education, Science and Technology, Republic of Korea
- NIH [GM076477]
- Hans W. Vahlteich Professorship
- National Research Foundation of Korea [2011-0031961] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
A biocatalytic platform that employs the final two monomodular type I polyketide synthases of the pikromycin pathway in vitro followed by direct appendage of D-desosamine and final C-H oxidation(s) in vivo was developed and applied toward the synthesis of a suite of 12- and 14-membered ring macrolide natural products. This methodology delivered both compound classes in 13 steps (longest linear sequence) from commercially available (R)-Roche ester in >10% overall yields.
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