期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 135, 期 10, 页码 3772-3775出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja400051d
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资金
- Leverhulme Trust
- Spanish Government
- EPSRC
- ERC
- VCI
- EPSRC [EP/I00548X/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/I00548X/1] Funding Source: researchfish
An organocatalytic aldehyde C-H bond arylation process for the synthesis of complex heteroaryl ketones has been developed. By exploiting the inherent electrophilicity of diaryliodonium salts, we have found that a commercial N-heterocyclic carbene catalyst promotes the union of heteroaryl aldehydes and these heteroaromatic electrophile equivalents in good yields. This straightforward catalytic protocol offers access to ketones bearing a diverse array of arene and heteroarene substituents that can subsequently be converted into molecules displaying structural motifs commonly found in medicinal agents.
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