期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 135, 期 4, 页码 1406-1414出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja3091615
关键词
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资金
- Penn State MRSEC under NSF [DMR-0820404]
Using fluorescence correlation spectroscopy, we show that the diffusive movements of catalase enzyme molecules increase in the presence of the substrate, hydrogen peroxide, in a concentration-dependent manner. Employing a microfluidic device to generate a substrate concentration gradient, we show that both catalase and urease enzyme molecules spread toward areas of higher substrate concentration, a form of chemotaxis at the molecular scale. Using glucose oxidase and glucose to generate a hydrogen peroxide gradient, we induce the migration of catalase toward glucose oxidase, thereby showing that chemically interconnected enzymes can be drawn together.
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