期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 135, 期 20, 页码 7442-7445出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja402922w
关键词
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资金
- National Science Foundation [DGE-1144469]
- California Institute of Technology
- Amgen
- Novartis
The first enantioselective Ni-catalyzed reductive acyl cross-coupling has been developed. Treatment of acid chlorides and racemic secondary benzyl chlorides with a Ni-II/bis(oxazoline) catalyst in the presence of Mn-0 as a stoichiometric reductant generates acyclic alpha,alpha-disubstituted ketones in good yields and high enantioselectivity without requiring stoichiometric chiral auxiliaries or pregeneration of organometallic reagents. The mild, base-free reaction conditions are tolerant of a variety of functional groups on both coupling partners.
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