期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 135, 期 43, 页码 16192-16197出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja407589e
关键词
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资金
- NIH [R01 GM097243]
- NSF [CHE-0650456]
The direct cross-coupling of two different electrophiles, such as an aryl halide with an alkyl halide, offers many advantages over conventional cross-coupling methods that require a carbon nucleophile. Despite its promise as a versatile synthetic strategy, a limited understanding of the mechanism and origin of cross selectivity has hindered progress in reaction development and design. Herein, we shed light on the mechanism for the nickel-catalyzed cross-electrophile coupling of aryl halides with alkyl halides and demonstrate that the selectivity arises from an unusual catalytic cycle that combines both polar and radical steps to form the new C-C bond.
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