期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 135, 期 19, 页码 7304-7311出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja401610p
关键词
-
资金
- National Science Foundation [CAREER-1057143]
- Boehringer-Ingleheim
- Amgen
- California Institute of Technology
An investigation of the intramolecular cyclopropanation reactions of alpha-diazo-beta-ketonitriles is reported. These studies reveal that alpha-diazo-beta-ketonitriles exhibit unique reactivity in their ability to undergo arene cyclopropanation reactions; other similar acceptor acceptor-substituted diazo substrates instead produce mixtures of C-H insertion and dimerization products. alpha-Diazo-beta-ketonitriles also undergo highly efficient intramolecular cyclopropanation of tri- and tetrasubstituted alkenes. In addition, the alpha-cyano-alpha-ketocyclopropane products are demonstrated to serve as substrates for S(N)2, S(N)2', and aldehyde cycloaddition reactions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据