期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 135, 期 24, 页码 9083-9090出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja4034999
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资金
- NIH NIGMS [R01GM100212]
- University of California Cancer Research Coordinating Committee
The first Negishi nickel-catalyzed stereospecific cross-coupling reaction of secondary benzylic esters is reported. A series of traceless directing groups is evaluated for ability to promote cross-coupling with dimethylzinc. Esters with a chelating thioether derived from commercially available 2-(methylthio)acetic acid are most effective. The products are formed in high yield and with excellent stereospecificity. A variety of functional groups are tolerated in the reaction including alkenes, alkynes, esters, amines, imides, and O-, S-, and N-heterocycles. The utility of this transformation is highlighted in the enantioselective synthesis of a retinoic acid receptor agonist and a fatty acid amide hydrolase inhibitor.
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