期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 135, 期 49, 页码 18347-18349出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja410686v
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资金
- University of Washington
- National Science Foundation
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1266359] Funding Source: National Science Foundation
A mild palladium-catalyzed cross-coupling of unsubstituted and 2-alkyl-substituted aziridines with arylboronic acid nucleophiles is presented. The reaction is highly regioselective and compatible with diverse functionality. A catalytic amount of base, a sterically demanding triarylphosphine ligand, and a phenol additive are critical to the success of the reaction. Coupling of a deuterium-labeled substrate established that ring opening of the aziridine occurs with inversion of stereochemistry.
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