期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 135, 期 2, 页码 616-619出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja3113752
关键词
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资金
- 973 Program [2013CB932800]
- NNSFC [20972148]
- CAS [KJCX2-EW-J02]
- China Postdoctoral Science Foundation [2011M500289, 2012T50078]
An unexpected C-H activation/C-C cross-coupling reaction has been found to occur between pyridine N-oxides and general nonactivated secondary and even tertiary alkyl bromides. It provides a practically useful approach for the synthesis of alkylated pyridine derivatives. Experimental observations indicated that the C-Br cleavage step involves a radical-type process. Thus, the title reaction provides a rather extraordinary example of Pd-catalyzed cross-coupling of secondary and tertiary aliphatic electrophiles.
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