期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 135, 期 35, 页码 13113-13120出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja405990z
关键词
-
资金
- NIH [AI 067854, AI 100645]
- American Cancer Society [PF-11-014-01-CDD]
- European Commission (Marie Curie International Outgoing Fellowship)
Critical to the search for an effective HIV-1 vaccine is the development of immunogens capable of inducing broadly neutralizing antibodies (BnAbs). A key first step in this process is to design immunogens that can be recognized by known BnAbs. The monoclonal antibody PG9 is a BnAb that neutralizes diverse strains of HIV-1 by targeting a conserved carbohydrate protein epitope in the variable 1 and 2 (V1V2) region of the viral envelope. Important for recognition are two closely spaced N-glycans at Asn(160) and Asn(156). Glycopeptides containing this synthetically challenging bis-N-glycosylated motif were prepared by convergent assembly, and were shown to be antigenic for PG9. Synthetic glycopeptides such as these may be useful for the development of HIV-1 vaccines based on the envelope V1V2 BnAb epitope.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据