期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 135, 期 16, 页码 6338-6344出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja401845e
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资金
- Office of Naval Research [N00014-09-1-1087]
- Welch Foundation [F-1151]
- Department of Science and Technology of India
- Defense Research and Development Organization of India
A fluorescent turn-on sensor for the selective and sensitive detection of sulfur mustard simulants in water that uses a metal-ion indicator displacement assay (IDA) has been devised. In this IDA approach, a sulfur mustard simulant (the analyte) is allowed to react with a dithiol (1) to form a podand (2). This podand has a strong affinity to bind with Cd2+ and displaces an indicator (4-methylesculetin, ME) from a Cd2+ indicator complex (8) to give a turn-on of fluorescence. The detection is rapid and highly selective, as we did not observe any interference from other electrophiles, even from the oxygen analogue of the mustard simulant. The protocol was successfully used for the detection of the simulant present on surfaces and in soil samples.
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