期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 135, 期 16, 页码 6030-6032出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja402806f
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资金
- MEXT [22000008, 23750100, 25105711]
- Chinese Scholarship Council
- Japan Society for the Promotion of Science [21-8684]
- Grants-in-Aid for Scientific Research [25105711, 22000008, 23750100] Funding Source: KAKEN
A 2,2-disubstituted propionamide bearing an 8-aminoquinolinyl group as the amide moiety can be arylated at the beta-methyl position with an organozinc reagent in the presence of an organic oxidant, a catalytic amount of an iron salt, and a biphosphine ligand at 50 degrees C. Various features of selectivity and reactivity suggest the formation of an organometallic intermediate via rate-determining C-H bond cleavage rather than a free-radical-type reaction pathway.
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