期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 135, 期 13, 页码 4970-4973出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja401606e
关键词
-
资金
- Welch Foundation [AX-1735]
- National Institute on Minority Health and Health Disparities from the National Institutes of Health [G12MD007591]
- Division Of Human Resource Development
- Direct For Education and Human Resources [1249284] Funding Source: National Science Foundation
We wish to report our preliminary results on the discovery and development of a catalytic, asymmetric beta-hydride elimination from vinyl Pd(II)-complexes derived from enol triflates to access chiral allenes. To achieve this, we developed a class of chiral phosphite ligands that demonstrate high enantioselectivity, allow access of either allene enantiomer, and are readily synthesized. The methodology is demonstrated on over 20 substrates, and application to the formal asymmetric total synthesis of the natural product, (+)-epibatidine, is also provided.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据