4.8 Article

Pd(II)-Catalyzed C-H Iodination Using Molecular I2 as the Sole Oxidant

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 135, 期 28, 页码 10326-10329

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AMER CHEMICAL SOC
DOI: 10.1021/ja4055492

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  1. Scripps Research Institute
  2. National Institutes of Health [NIGMS 1 R01 GM102265-01]
  3. Bristol-Myers Squibb Co.

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Pd-catalyzed ortho-C-H iodination directed by a weakly coordinating amide auxiliary using h as the sole oxidant was developed. This reaction is compatible with a wide range of heterocycles including pyridines, imidazoles, oxazoles, thiazoles, isoxazoles, and pyrazoles.

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