4.8 Article

Cross-Coupling of Remote meta-C-H Bonds Directed by a U-Shaped Template

期刊

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 135, 期 48, 页码 18056-18059

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AMER CHEMICAL SOC
DOI: 10.1021/ja410760f

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资金

  1. Scripps Research Institute
  2. National Institutes of Health [NIGMS 1 R01 GM102265-01]
  3. China Scholarship Council
  4. Austrian Science Foundation (FWF) [J 3424-N28]
  5. Austrian Science Fund (FWF) [J 3424] Funding Source: researchfish

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meta-C-H arylation and methylation of 3-phenylpropanoic acid and phenolic derivatives were developed using an easily removable nitrile template. The combination of a weakly coordinating U-shaped template and mono-protected amino acid ligand was crucial for the cross-coupling of C-H bonds with organoborons.

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