期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 135, 期 29, 页码 10626-10629出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja4052075
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资金
- NIH-NIGMS [R01GM080269]
- Amgen
- Gordon and Betty Moore Foundation
- Caltech
- Shanghai Institute of Organic Chemistry (SIOC)
Highly congested vicinal stereocenters comprised of tertiary and all-carbon quaternary centers were generated via Ir-catalyzed asymmetric allylic alkylation of beta-ketoesters. These catalytic reactions proceed in excellent yields with a broad scope on either reaction partner and with outstanding regio-, diastereo-, and enantiocontrol. Implementation of a subsequent Pd-catalyzed alkylation affords dialkylated products with pinpoint stereochemical control of both chiral centers.
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