期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 136, 期 1, 页码 108-111出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja411737c
关键词
-
资金
- NIH [R00 GM087306]
- Princeton University
A highly selective and convenient method for the synthesis of pyrophosphopeptides in solution is reported. The remarkable compatibility with functional groups (alcohol, thiol, amine, carboxylic acid) in the peptide substrates suggests that the intrinsic nucleophilicity of the phosphoserine residue is much higher than previously appreciated. Because the methodology operates in polar solvents, including water, a broad range of pyrophosphopeptides can be accessed. We envision these peptides will find widespread applications in the development of mass spectrometry and antibody-based detection methods for pyrophosphoproteins.
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