期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 135, 期 13, 页码 4958-4961出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja401146v
关键词
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资金
- Fonds der Chemischen Industrie
- European Research Council [ERC-227763]
- Sonderfor-schungbereich of the German Science Foundation (DFG) [SFB-749]
A formal regioselective cross-coupling of various pyridines with alkyl and aryl groups can be achieved by a BF3 center dot OEt2-mediated addition of Grignard or organozinc reagents to pyridines bearing various substituents (chloro, bromo, cyano, vinyl, phenyl, carbethoxy, nitro, etc.) followed by an oxidative aromatization mediated by chloranil. Good regioselectivity and wide functional group tolerance make this method very versatile for the preparation of polyfunctional pyridines. No transition-metal catalyst is required in these coupling reactions.
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