期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 135, 期 20, 页码 7705-7712出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja4015748
关键词
-
资金
- NSF [CHE-0750303, EXP-LA 0731153]
- BGSU
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0750303] Funding Source: National Science Foundation
A supramolecular sensor array consisting of eight chemosensors embedded in a hydrogel matrix was used to sense carboxylate drugs. The discriminatory power of the array has been evaluated using principal component analysis and linear discriminant analysis. The eight-member sensor array has been shown to accurately identify 14 carboxylates in water with 100% classification accuracy. To demonstrate the potential for practical utility in the physiological environment, analysis of carboxylate drugs in human urine was also performed achieving 100% correct classification. In addition, the array performance in semiquantitative identification of nonsteroidal anti-inflammatory drugs has been investigated, and the results show that the sensor array is able to differentiate six typical nonsteroidal anti-inflammatory drugs at concentrations of 0.5-100 ppm. This illustrates the potential utility of the designed sensor array for diagnostic and environmental monitoring applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据