期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 135, 期 22, 页码 8193-8196出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja4040945
关键词
-
资金
- Shenzhen special funds for the development of biomedicine, Internet, new energy, and new material industries [JC201104210111A, JC201104210112A]
- Shenzhen innovation funds [GJHZ20120614144733420]
- Shenzhen Peacock Program [KQTD201103]
Tetrahydroquinolines containing two quaternary stereogenic centers were synthesized with excellent ee and dr via a four-component cyclization reaction catalyzed by a chiral phosphoric acid. High chemoselectivity was achieved by differentiating anilines with similar reactivities to yield diverse hybrid products. The chirality of the quaternary C4 atom of the 4-aminotetrahydroquinoline products was found to undergo highly stereoselective inversion, enabling facile functionalization using a wide range of nucleophiles (C, O, N, and S).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据