4.8 Article

Selective Cavitand-Mediated Endocytosis of Targeted Imaging Agents into Live Cells

期刊

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 135, 期 19, 页码 7090-7093

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AMER CHEMICAL SOC
DOI: 10.1021/ja401273g

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资金

  1. National Science Foundation [CHE-1151773, CHE-1059050, DBI-0722757]
  2. National Institutes of Health [SC2CA167636, R01 DK082779, RNS071160A, RNS072298A]
  3. Division Of Chemistry
  4. Direct For Mathematical & Physical Scien [1059050, 1151773] Funding Source: National Science Foundation

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A water-soluble synthetic receptor molecule is capable of selective, controlled endocytosis of a specifically tagged target molecule in different types of living human cells. The presence of suitable choline-derived binding handles is essential for the molecular recognition and transport process, allowing selective guest transport and imaging of cancer cells.

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