期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 135, 期 7, 页码 2403-2406出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja3089857
关键词
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资金
- National Natural Science Foundation of China [21075120, 21190040]
- 973 Program [2010CB933600, 2011CB911000]
Photoinduced electron transfer (PET) has been observed for the first time between DNA/Ag fluorescent nanoclusters (NCs) and G-quadruplex/hemin complexes, accompanied by a decrease in the fluorescence of the DNA/Ag NCs. In this PET process, a parallel G-quadruplex and the sensing sequences are blocked by a duplex. The specific combination of targets with the sensing sequence triggers the release of the G-quadruplex and allows it to fold properly and bind hemin to form a stable G-quadruplex/hemin complex. The complex proves favorable for PET because it makes the G-quadruplex bind hemin tightly, which promotes the electron transfer from the DNA/Ag NCs to the hemin Fe-III center, thus resulting in a decrease in the fluorescence intensity of the DNA/Ag NCs. This novel PET system enables the specific and versatile detection of target biomolecules such as DNA and ATP with high sensitivity based on the choices of different target sequences.
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