期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 135, 期 46, 页码 17306-17309出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja410060e
关键词
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资金
- National Science Foundation of China [21222201, 21271147, 51202192, J1210057]
- Thousand Plan Youth program
- Ministry of Education of China [20126101120011]
- Northwest University
Intermolecular annulation reactions of 1-aryl-2-naphthols with internal alkynes proceed efficiently in the presence of a Ru catalyst and a Cu oxidant to generate spirocyclic compounds by sequential cleavage of the C(sp(2))-H bond, migratory insertion of the alkyne, and dearomatization of the naphthyl ring. Various spirocyclic molecules bearing an all-carbon quaternary stereocenter could be obtained by this novel method with good yields and excellent regioselectivity, and the current process tolerates a variety of synthetically important functional groups.
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