期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 134, 期 22, 页码 9066-9069出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja302691r
关键词
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资金
- National Natural Science Foundation of China [21121062, 20932008, 21072207]
- 973 Program [2009CB825300]
- CAS
A Ni-catalyzed asymmetric ring-opening reaction of 2-substituted cyclopropane-1,1-dicarboxylates with aliphatic amines has been accomplished using the chiral indane-trisoxazoline (In-TOX) ligand. This highly enantioselective reaction provides an efficient approach to a variety of chiral gamma-substituted gamma-amino acid derivatives, which are readily transformed into multifunctionalized piperidines and gamma-lactams. The single-crystal X-ray structure of the TOX-Ni complex is provided, and the role of the side arm in the chiral ligand is discussed.
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