期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 134, 期 28, 页码 11358-11361出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja304180y
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资金
- Duke University Faculty Research Funds
- National Institutes of Health [R01 EB006201]
- Immunolight, LLC
- NIH training grant [T32 EB001040]
Gold nanoparticles have great potential in plasmonic photothermal therapy (photothermolysis), but their intracellular delivery and photothermolysis efficiency have yet to be optimized. We show that TAT-peptide-functionalized gold nanostars (NS) enter cells significantly more than bare or PEGylated NS. The cellular uptake mechanism involves actin-driven lipid raft-mediated macropinocytosis, where particles primarily accumulate in macropinosomes but may also leak out: into the cytoplasm. After 4-h incubation of TAT-NS on BT549 breast cancer cells, photothermolysis was accomplished using 850 nm pulsed laser under 0.2 W/cm(2) irradiation, below the maximal permissible exposure of skin. These results demonstrate the enhanced intracellular delivery and efficient photothermolysis of TAT-NS, promising agents in cancer therapy.
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