期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 134, 期 45, 页码 18542-18545出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja308772d
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资金
- IUPAC Transnational Pilot Call in Polymer Chemistry
- German Research Foundation (DFG) [SCHL 566/5-1]
Copolypeptides of L-glutamate and glucosylated L-/DL-allyl- or DL-propargylglycine were synthesized by ring opening polymerization and thiol-ene/yne photochemistry in aqueous solution, allowing the mild introduction. of sugar units (here, glucose) in the final step. The glucosylatecl and non-glucosylated samples adopt a random coil conformation in neutral and basic media and an alpha-helical conformation in acidic media, the helical content depending on the number and configuration of allyl-/propargylglycine units. The glucocopolypeptides unveil enhanced helical stability and solubility down to pH 3.5. Turbidity assays proved the selective binding of the polymers to the plant lectin concanavalin A.
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