期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 134, 期 30, 页码 12370-12373出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja3046684
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资金
- NIH [GM084022, SlO RR04981-01]
- NSF [cHE-9629688]
The regioselective and enantioselective oxyamination of alkenes with N-sulfonyl oxaziridines is catalyzed by a novel iron(II) bis(oxazoline) complex. This process affords oxazolidine products that can be easily manipulated to yield highly enantioenriched free amino alcohols. The regioselectivity of this process is complementary to that obtained from the analogous copper(II)-catalyzed reaction. Thus, both regioisomers of enantioenriched 1,2-aminoalcohols can be obtained using oxaziridine-mediated oxyamination reactions, and the overall sense of regiochemistry can be controlled using the appropriate choice of inexpensive first-row transition metal catalyst.
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