期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 134, 期 44, 页码 18197-18200出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja3084434
关键词
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资金
- U.S. National Science Foundation (NSF) [CHE-1058794]
- UCSB Partnership for International Research and Education in Electron Chemistry and Catalysis at Interfaces (NSF) [OISE-0968399]
- Institute for Collaborative Biotechnologies through the U.S. Army Research Office [DAAD19-03-D-0004]
- NCRR Shared Instrumentation NIH Grant [1S10RR017753-01]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1058794] Funding Source: National Science Foundation
- Office Of The Director
- Office Of Internatl Science &Engineering [968399] Funding Source: National Science Foundation
The water-soluble rhenium(I) complex fac-[Re(bpy)(CO)(3)(thp)](+) (1) [CF3SO3- salt; bpy = 2,2'-bipyridine, thp = tris(hydroxymethyl)phosphine] is both strongly luminescent and photoactive toward carbon monoxide release. It is stable in aerated aqueous media, is incorporated into cells from the human prostatic carcinoma cell line PPC-1, and shows no apparent cytotoxicity. Furthermore, the solvated Re(I) photoproduct of CO release (2) is also luminescent, a feature that allows one to track the transformation of 1 to 2 inside such cells using confocal fluorescence microscopy. In this context, 1 is a very promising candidate as a photo-activated CO releasing moiety (photoCORM) with potential therapeutic applications.
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