期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 134, 期 4, 页码 1902-1905出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja207366k
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资金
- National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services [HHSN268201000043C]
- Frechet various donors fund
- Alexander von Humboldt Foundation (AvH)
A water-soluble polyphosphonium polymer was synthesized and directly compared with its ammonium analog in terms of siRNA delivery. The triethylphosphonium polymer shows transfection efficiency up to 65% with 100% cell viability, whereas the best result obtained for the ammonium analog reaches only 25% transfection with 85% cell viability. Moreover, the nature of the alkyl substituents on the phosphonium cations is shown to have an important influence on the transfection efficiency and toxicity of the polyplexes. The present results show that the use of positively charged phosphonium groups is a worthy choice to achieve a good balance between toxicity and transfection efficiency in gene delivery systems.
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