期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 134, 期 19, 页码 8094-8097出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja3030164
关键词
-
资金
- NIGMS [GM 72586]
- Amgen
- Roche
Cross-coupling reactions are among the most widely utilized methods for C-C bond formation; however, the requirement of preactivated starting materials still presents a major limitation. Methods that take direct advantage of the inherent reactivity of the C-H bond offer an efficient alternative to these methods, negating the requirement for substrate preactivation. In this process, two chemically distinct activation events culminate in the formation of the desired C-C bond with loss of H-2 as the only byproduct. Herein we report the catalytic asymmetric alpha-acylation of tertiary amines with aldehydes facilitated by the combination of chiral N-heterocyclic carbene catalysis and photoredox catalysis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据