期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 134, 期 29, 页码 11974-11976出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja305734x
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资金
- Cancer Research UK
- Cancer Research UK [12488] Funding Source: researchfish
Telomeric repeat-containing RNA (TERRA) is important for telomere regulation, but the structural basis for how TERRA localizes to chromosome ends is unknown. Here we report on studies exploring whether the TERRA G-quadruplex structure is critical for binding to telomeres. We demonstrate that the telomeric protein TRF2 binds TERRA via interactions that necessitate the formation of a G-quadruplex structure rather than the TERRA sequence per se. We also show that TRF2 simultaneously binds TERRA and telomeric duplex or G-quadruplex DNA. These observations suggest that the TERRA G-quadruplex is a key feature of telomere organization.
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