期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 135, 期 5, 页码 1665-1668出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja3092517
关键词
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资金
- Max-Planck-Society
- Arthur C. Cope Foundation
Catalytic asymmetric reduction of prochiral ketones of type 4-alkylidene cyclohexanone with formation of the corresponding axially chiral R-configurated alcohols (up to 99% ee) was achieved using alcohol dehydrogenases, whereas chiral transition-metal catalysts fail. Reversal of enantioselectivity proved to be possible by directed evolution based on saturation mutagenesis (up to 98% ee (S)). Utilization of ketone with a vinyl bromide moiety allows respective R- and S-alcohols to be exploited as key compounds in Pd-catalyzed cascade reactions.
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