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Eliana Marisa Ramos et al.
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Xing Guo et al.
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Sven H. Stuewe et al.
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A. Giralt et al.
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Ulziibat P. Shirendeb et al.
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Early Alterations of Brain Cellular Energy Homeostasis in Huntington Disease Models
Fanny Mochel et al.
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Jianguang Ji et al.
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Youngnam N. Jin et al.
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Fiona M. Menzies et al.
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Vishal M. Gohil et al.
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Jessie C. Jacobsen et al.
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Eugene P. Rhee et al.
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Wenjun Song et al.
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Thomas J. Wang et al.
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Rajnish K. Chaturvedi et al.
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Systemic energy homeostasis in Huntington's disease patients
N. Ahmad Aziz et al.
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Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease
Marta Martinez-Vicente et al.
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Chiara Zuccato et al.
PHYSIOLOGICAL REVIEWS (2010)
A plasma signature of human mitochondrial disease revealed through metabolic profiling of spent media from cultured muscle cells
Oded Shaham et al.
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Shuqiu Zheng et al.
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In situ 3D magnetic resonance metabolic imaging of microwave-irradiated rodent brain: a new tool for metabolomics research
Robin A. de Graaf et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Autophagy regulates lipid metabolism
Rajat Singh et al.
NATURE (2009)
Dietary intake in adults at risk for Huntington disease Analysis of PHAROS Research Participants
K. Marder et al.
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A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease
Maria Bjorkqvist et al.
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Weight loss in neurodegenerative disorders
N. Ahmad Aziz et al.
JOURNAL OF NEUROLOGY (2008)
Weight loss in Huntington disease increases with higher CAG repeat number
N. A. Aziz et al.
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Jong-Min Lee et al.
PLOS GENETICS (2007)
Neurochemical changes in Huntington R6/2 mouse striatum detected by in vivo 1H NMR spectroscopy
Ivan Tkac et al.
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Selective defect of in vivo glycolysis in early Huntington's disease striatum
William J. Powers et al.
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Mutant huntingtin inhibits clathrin-independent endocytosis and causes accumulation of cholesterol in vitro and in vivo
Eugenia Trushina et al.
HUMAN MOLECULAR GENETICS (2006)
Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1α in Huntington's disease neurodegeneration
Patrick Weydt et al.
CELL METABOLISM (2006)
Transcriptional repression of PGC-α by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration
Libin Cui et al.
CELL (2006)
Genetic background modifies nuclear mutant huntingtin accumulation and HD CAG repeat instability in Huntington's disease knock-in mice
Alejandro Lloret et al.
HUMAN MOLECULAR GENETICS (2006)
Body weight is modulated by levels of full-length Huntingtin
JM Van Raamsdonk et al.
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Dysfunction of the cholesterol biosynthetic pathway in Huntington's disease
M Valenza et al.
JOURNAL OF NEUROSCIENCE (2005)
HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism
IS Seong et al.
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Discovering statistically significant pathways in expression profiling studies
L Tian et al.
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Evidence for more widespread cerebral pathology in early HD - An MRI-based morphometric analysis
HD Rosas et al.
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Dominant phenotypes produced by the HD mutation in STHdhQ111 striatal cells
F Trettel et al.
HUMAN MOLECULAR GENETICS (2000)