期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 134, 期 9, 页码 3987-3990出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja2112405
关键词
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资金
- U.S. Department of Energy, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering [DE-AC02-05CH11231]
- National Science Foundation [CHE-0957655]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0957655] Funding Source: National Science Foundation
We have recently demonstrated that sensitive and chemically specific NMR spectra can be recorded in the absence of a magnetic field using hydrogenative parahydrogen induced polarization (PHIP)(1-3) and detection with an optical atomic magnetometer. Here, we show that non-hydrogenative para-hydrogen-induced polarization(4-6) (NH-PHIP) can also dramatically enhance the sensitivity of zero-field NMR. We demonstrate the detection of pyridine, at concentrations as low as 6 mM in a sample volume of 250 mu L, with sufficient sensitivity to resolve all identifying spectral features, as supported by numerical simulations. Because the NH-PHIP mechanism is nonreactive, operates in situ, and eliminates the need for a prepolarizing magnet, its combination with optical atomic magnetometry will greatly broaden the analytical capabilities of zero-field and low-field NMR.
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