期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 134, 期 36, 页码 14638-14641出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja307045r
关键词
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资金
- NSFC [20925207, 21072010, 20821062]
- 973 Project from the MOST of China [2009CB825300]
Direct application of benzyl alcohols (or their magnesium salts) as electrophiles in various reactions with Grignard reagents has been developed via transition metal-catalyzed sp(3) C-O bond activation. Ni complex was found to be an efficient catalyst for the first direct cross coupling of benzyl alcohols with aryl/alkyl Grignard reagents, while Fe, Co, or Ni catalysts could promote the unprecedented conversion of benzyl alcohols to benzyl Grignard reagents in the presence of (n)hexylMgCl. These methods offer straightforward pathways to transform benzyl alcohols into a variety of functionalities.
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