期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 134, 期 12, 页码 5697-5705出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja3011397
关键词
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资金
- National Science Foundation [CHE-1111316]
- CREAM Mass Spectrometry Facility (University of Louisville)
- NSF/EPSCoR [EPS-0447479]
Gold catalysis is considered one of the most important breakthroughs in organic synthesis during the past decade, but a rational understanding of ligand effects in gold catalysis is lacking. Most gold-catalyzed reactions go through three major stages: (i) electronic activation of alkyne (or allene) to generate a vinyl gold intermediate; (ii) protodeauration to generate the product and regenerate the cationic gold catalyst; (iii) decay of the active gold catalyst. Our research provides a clearer understanding of how ligands influence each of the three stages in the gold catalytic cycle. What is even more important, by not focusing on a particular gold-catalyzed reaction, we have been able to categorize most gold-catalyzed reactions and propose a ligand design protocol for each category of gold-catalyzed reactions.
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