期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 134, 期 42, 页码 17424-17427出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja3081023
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资金
- ONR
- DOE
- ARO
- NSF
- NIH
- Center for BioInspired Solar Fuel Production, an Energy Frontier Research Center
- DOE BES [DE-SC0001016]
- DOD-ONR
- U.S. Department of Energy (DOE) [DE-SC0001016] Funding Source: U.S. Department of Energy (DOE)
The assembly and isolation of DNA oligonucleotide-functionalized gold nanoparticles (AuNPs) has become a well-developed technology that is based on the strong bonding interactions between gold and thiolated DNA. However, achieving DNA-functionalized semiconductor quantum dots (QDs) that are robust enough to withstand precipitation at high temperature and ionic strength through simple attachment of modified DNA to the QD surface remains a challenge. We report the synthesis of stable core/shell (1-20 monolayers) QD-DNA conjugates in which the end of the phosphorothiolated oligonucleotide (5-10 nucleotides) is embedded within the shell of the QD. These reliable QD-DNA conjugates exhibit excellent chemical and photonic stability, colloidal stability over a wide pH range (4-12) and at high salt concentrations (>100 mM Na+ or Mg2+), bright fluorescence emission with quantum yields of up to 70%, and broad spectral tunability with emission ranging from the UV to the NIR (360-800 nm).
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