期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 134, 期 36, 页码 14646-14649出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja304674d
关键词
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资金
- U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences User Facility [DE-AC02-06CH11357]
- Department of Energy, Office of Science, Workforce Development for Teachers and Scientists
- Division of Educational Programs at ANL
- U.S. Department of Energy, US DOE-BES [DE-FG02-00ER45810]
Long fibers assembled from peptide amphiphiles capable of binding the metalloporphyrin zinc protoporphyrin IX ((PPIX)Zn) have been synthesized. Rational peptide design was employed to generate a peptide, c16-AHL(3)K(3)-CO2H, capable of forming a beta-sheet structure that propagates into larger fibrous structures. A porphyrin-binding site, a single histidine, was engineered into the peptide sequence in order to bind (PPIX)Zn to provide photophysical functionality. The resulting system indicates control from the molecular level to the macromolecular level with a high order of porphyrin organization. UV/visible and circular dichroism spectroscopies were employed to detail molecular organization, whereas electron microscopy and atomic force microscopy aided in macromolecular characterization. Preliminary picosecond transient absorption data are also reported. Reduced hemin, (PPIX)Fe-II, was also employed to highlight the material's versatility and tunability.
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