期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 134, 期 23, 页码 9644-9656出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja300538s
关键词
-
资金
- MICINN (Spain) [CSD-2010- 00065, CTQ2009-14288-C04-01]
- GVA [PROMETEO 2011/008]
- Instituto de Salud Carlos III-Institut Catala de la Salut in Catalonia
- Ajuntament de Valencia
- MICINN
DNA interaction with scorpiand azamacrocycles has been achieved through modulation of their binding affinities. Studies performed with different experimental techniques provided evidence that pH or metal-driven molecular reorganizations of these ligands regulate their ability to interact with calf thymus DNA (ctDNA) through an intercalative mode. Interestingly enough, metal-driven molecular reorganizations serve to increase or decrease the biological activities of these compounds significantly.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据