期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 134, 期 38, 页码 15724-15727出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja3079829
关键词
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资金
- NSF [CHE-1012578]
- NIH NIBIB [EB008484]
- Nebraska Research Initiative
- NIH NIBIB (Denver) [EB002807]
We report a molecular design that provides an intravenously injectable organic radical contrast agent (ORCA) for which the molecular water relaxivity (r(1)) is ca. 5 mM(-1) s(-1). The ORCA is based on spirocyclohexyl nitroxide radicals and poly(ethylene glycol) chains conjugated to a fourth-generation polypropylenimine dendrimer scaffold. The metal-free ORCA has a long shelf life and provides selectively enhanced magnetic resonance imaging in mice for over 1 h.
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