期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 134, 期 16, 页码 6932-6935出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja301259v
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资金
- Air Force Office of Scientific Research [FA9550-10-1-0395]
- MICINN
Proteases are overexpressed in most cancers and proteolytic activity has been shown to be a viable marker for cancer imaging in vivo. Herein, we describe the synthesis of luminescence-quenched shell cross-linked nanoparticles as photonic nanoprobes for protease sensing. Protease sensing scheme is based on a turn-on mechanism where the protease cleaves peptide cross-linkers of the fluorescence-quenched shell cross-linked NP (OFF state) leading to a highly emissive non-cross linked NP (ON state). The cross-linked particles can be strained by exposure to a good solvent and proteolysis allows for particle expansion (swelling) and a recovery of the luminescence.
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