期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 134, 期 40, 页码 16512-16515出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja307532d
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资金
- National Center for Research Resources [5P30RR031160-03]
- National Institute of General Medical Sciences, National Institutes of Health [8P30GM103519-03]
- National Science Foundation [OCI-1053575]
Molecular dynamics simulations of the A(2A) adenosine receptor totaling 1.4 mu s show clear evidence for specific sites mediating interactions between adenosine-bound A(2A) and cholesterol. The strongest evidence is for three binding sites. Two are in the extracellular leaflet, with one site interacting with helices VII and I, and the other with helices II and III. One site is located in the intracellular leaflet, interacting with helices III and IV. One of our three predicted binding sites is confirmed by a just-published high-resolution structure of A(2A) cocrystallized with an antagonist.
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