期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 134, 期 3, 页码 1770-1774出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja209719k
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资金
- Wyss Institute for Biologically Inspired Engineering, ONR [N000014091118]
- NIH New Innovator [1DP20DO04641-01]
- Danish National Research Foundation
Scaffolded DNA origami has been proven to be a powerful and efficient approach to construct two-dimensional or three-dimensional objects with great complexity. Multilayer DNA origami has been demonstrated with helices packing along either honeycomb-lattice geometry or square-lattice geometry. Here we report successful folding of multilayer DNA origami with helices arranged on a close-packed hexagonal lattice. This arrangement yields a higher density of helical packing and therefore higher resolution of spatial addressing than has been shown previously. We also demonstrate hybrid multilayer DNA origami with honeycomb-lattice, square-lattice, and hexagonal-lattice packing of helices all in one design. The availability of hexagonal close-packing of helices extends our ability to build complex structures using DNA nanotechnology.
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