期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 134, 期 45, 页码 18518-18521出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja308318p
关键词
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资金
- Harvard University
- Corning Foundation
- Searle Scholars Program
- NIH [GM095450]
- Hershel Smith Fellowship program
The cylindrocyclophanes are a family of natural products that share a remarkable paracyclophane carbon scaffold. Using genome sequencing and bioinformatic analyses; we have discovered a biosynthetic gene cluster involved in the assembly of cylindrocyclophane F. Through a combination of in vitro enzyme characterization and feeding Studies, We Confirm the connection between this gene cluster and cylindrocyclophane production, elucidate the chemical events involved in initiating and terminating an unusual type I polyketide synthase assembly line, and discover that macrocycle assembly involves functionalization of an unactivated carbon center.
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