期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 134, 期 17, 页码 7238-7241出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja3013177
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资金
- Grants-in-Aid for Scientific Research [23760758] Funding Source: KAKEN
Biosynthesis of glycoproteins in the endoplasmic reticulum employs a quality control system, which discriminates and excludes misfolded malfunctional glycoproteins from a correctly folded one. As chemical tools to study the glycoprotein quality control system, we systematically synthesized misfolded homogeneous glycoproteins bearing a high-mannose type oligosaccharide via oxidative misfolding of a chemically synthesized homogeneous glycopeptide. The endoplasmic reticulum folding sensor enzyme, UDP-glucose:glycoprotein glucosyltransferase (UGGT), recognizes a specific folding intermediate, which exhibits a molten globule-like hydrophobic nature.
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