4.8 Article

Programmable Self-Assembly of Antibody-Oligonucleotide Conjugates as Small Molecule and Protein Carriers

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 134, 期 6, 页码 2895-2897

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AMER CHEMICAL SOC
DOI: 10.1021/ja210894g

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  1. National Institutes of Health [CA120116, CA125360]
  2. Academic Health Center at University of Minnesota

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Dihydrofolate reductase single-chain variable fragment (scFv) fusion proteins can be used for the targeted cellular delivery of oligonucleotides, conjugated small molecules, and proteins via labeling of oligonucleotides by bis-methotrexate.

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