期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 134, 期 11, 页码 5415-5422出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja300620z
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资金
- Bundesministerium fur Bildung und Forschung (BMBF) [0315591A]
- Jena School for Microbial Communication (JSMC)
The bacterium Cupriavidus necator H16 produces a family of linear lipopeptides when grown under low iron conditions. The structural composition of these molecules, exemplified by the main metabolite cupriachelin, is reminiscent of siderophores that are excreted by marine bacteria. Comparable to marine siderophores, the ferric form of cupriachelin exhibits photoreactive properties. Exposure to UV light induces an oxidation of its peptidic backbone and a concomitant reduction of the coordinated Fe(III). Here, we report the genomics-inspired isolation and structural characterization of cupriachelin as well as its encoding gene cluster, which was identified by insertional mutagenesis. Based upon the functional characterization of adenylation domain specificity, a model for cupriachelin biosynthesis is proposed.
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